FOXO4-DRI Research Peptide

FOXO4-DRI Research Peptide

Category: Senolytic Peptide Form: Lyophilized powder Intended Use: Laboratory research only — not for human or animal consumption

Overview

FOXO4-DRI is a cell-penetrating, D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 within senescent (“zombie”) cells. By interfering with this interaction, FOXO4-DRI causes nuclear exclusion of p53 and selectively triggers apoptosis in senescent cells while sparing healthy, non-senescent cells. It is one of the most widely cited compounds in senescent-cell-clearance research and is supplied here strictly for use in qualified laboratory research settings.

Specifications

• Purity:≥98% (see Certificate of Analysis for batch-specific results)
• Sequence class: D-retro-inverso peptide derived from the FOXO4 sequence
• Appearance:White lyophilized powder
• Storage: Store lyophilized powder at -20°C; keep reconstituted solution refrigerated at 2–8°C and use within the timeframe specified on the Certificate of Analysis
• Packaging:[vial size/quantity — insert per SKU]
• CAS/reference number:[insert if applicable]

Quality Assurance

Each batch is accompanied by a third-party Certificate of Analysis (COA) verifying purity and identity. COAs are available on request or via the product page prior to purchase.

Research Applications

FOXO4-DRI has been referenced extensively in published cellular senescence and aging-biology literature, including studies on chondrocyte senescence, endothelial and vascular aging, keloid fibroblast senescence, and tissue restoration in mouse models. It is intended solely to support in vitro or preclinical research protocols investigating senescence pathways, the FOXO4–p53 axis, and related mechanisms — findings to date come from cell culture and animal studies only; no human clinical trials have been conducted.

Important Notice

This product is sold exclusively for laboratory and research purposes. It is not approved by the FDA, MHRA, or any regulatory body for human or veterinary use, and is not a drug, dietary supplement, or cosmetic. It must not be used for diagnostic, therapeutic, or any other human or animal application. By purchasing, the buyer confirms they are a qualified researcher or institution acquiring this product for legitimate research use only, and assumes full responsibility for compliance with all applicable laws and regulations governing its handling and use.